Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224566 | 0.90 | MAPK14 (0.47) | MAPK14MAPTLMNATSHRHTT | |
| SCHEMBL5217387 | 0.90 | CASR (0.41) | MAPK14MAPTLMNATSHRHTT | |
| SCHEMBL1154530 | 0.85 | MAPK14 (0.46) | MAPK14MAPTLMNATSHRCASR | |
| SCHEMBL1154474 | 0.85 | CYP11B1 (0.43) | MAPTLMNATSHRHTTCYP11B1 | |
| SCHEMBL5217026 | 0.84 | MAOB (0.42) | MAPTLMNATSHRHTTCASR | |
| SCHEMBL5220371 | 0.82 | HTR2C (0.44) | CASRNPC1RAB9AMRGPRX4HTR2C | |
| SCHEMBL5216704 | 0.82 | MAPT (0.42) | MAPK14MAPTLMNATSHRHTT | |
| SCHEMBL1154302 | 0.82 | LMNA (0.43) | MAPTLMNATSHRHTTCASR | |
| SCHEMBL1155054 | 0.82 | NPC1 (0.52) | MAPTLMNATSHRHTTCASR | |
| SCHEMBL5215622 | 0.82 | CYP11B1 (0.46) | MAPTLMNATSHRHTTCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | disclosed |