Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219798 | 0.91 | TAAR1 (0.48) | MAOBABCB1TDP1SQORKDM4E | |
| SCHEMBL5222695 | 0.84 | MAPK14 (0.40) | NPC1RAB9ALMNAMAPTTSHR | |
| SCHEMBL5217387 | 0.82 | CASR (0.41) | MAOBNPC1RAB9ALMNAMAPT | |
| SCHEMBL1154474 | 0.81 | CYP11B1 (0.43) | NPC1RAB9ALMNAMAPTTSHR | |
| SCHEMBL5224566 | 0.80 | MAPK14 (0.47) | MAOBNPC1LMNAMAPTTSHR | |
| SCHEMBL1154302 | 0.80 | LMNA (0.43) | MAOBNPC1RAB9ALMNAMAPT | |
| SCHEMBL5225071 | 0.80 | CASR (0.51) | LMNAMAPTTSHRHTTCYP2D6 | |
| SCHEMBL5220371 | 0.78 | HTR2C (0.44) | MAOBNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL1154627 | 0.78 | SQOR (0.45) | NPC1RAB9ALMNAMAPTTSHR | |
| SCHEMBL5216704 | 0.78 | MAPT (0.42) | NPC1RAB9ALMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | disclosed |