Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226722 | 0.89 | KMT2A (0.43) | MEN1KMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL5225138 | 0.88 | MEN1 (0.43) | KDM1AMAPKAPK2GSK3BCNR1CNR2 | |
| SCHEMBL5223322 | 0.83 | BTK (0.50) | THRBKDM4ENPSR1ALDH1A1MAPT | |
| SCHEMBL5226694 | 0.82 | KDM4E (0.43) | KMT2AKDM4ECYP3A4NPC1 | |
| SCHEMBL5224317 | 0.80 | POLB (0.57) | CNR1CNR2ADORA1MEN1KMT2A | |
| SCHEMBL5224164 | 0.79 | ADORA1 (0.49) | KDM1ACNR1CNR2ADORA1MEN1 | |
| SCHEMBL5228063 | 0.78 | KMT2A (0.40) | MEN1KMT2ARXFP1KDM4ENPSR1 | |
| SCHEMBL5224031 | 0.77 | CNR1 (0.38) | CNR1CNR2STAT3KMT2AKDM4E | |
| SCHEMBL5221905 | 0.77 | APP (0.49) | GSK3BTHRBMEN1KMT2AKDM4E | |
| SCHEMBL5222128 | 0.76 | KMT2A (0.38) | MEN1KMT2AKDM4ENPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |