Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | GCGR | P47871 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226722 | 0.93 | KMT2A (0.43) | KDM4EBTKKMT2ANPC1 | |
| SCHEMBL5223322 | 0.87 | BTK (0.50) | KDM4EBTKNPC1 | |
| SCHEMBL5223318 | 0.82 | KDM1A (0.48) | KDM4ECYP3A4KMT2ANPC1 | |
| SCHEMBL5228063 | 0.82 | KMT2A (0.40) | KDM4EMAPK14GCGRCYP3A4KMT2A | |
| SCHEMBL5223530 | 0.81 | MAPK14 (0.46) | KDM4EUSP2MAPK14GCGRMAPK11 | |
| SCHEMBL5224031 | 0.81 | CNR1 (0.38) | KDM4ERPS6KA3KMT2ANPC1 | |
| SCHEMBL5221905 | 0.80 | APP (0.49) | KDM4EUSP2KMT2ANPC1 | |
| SCHEMBL5222128 | 0.79 | KMT2A (0.38) | KDM4ERPS6KA3KMT2ANPC1 | |
| SCHEMBL5226884 | 0.78 | MAPK14 (0.50) | KDM4EUSP2MAPK14GCGRMAPK11 | |
| SCHEMBL5224995 | 0.77 | RPS6KA3 (0.37) | KDM4ERPS6KA3KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |