Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226722 | 0.88 | KMT2A (0.43) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL5224031 | 0.85 | CNR1 (0.38) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL5222128 | 0.83 | KMT2A (0.38) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL5223322 | 0.83 | BTK (0.50) | NPC1RAB9AMAPTKDM4ENPSR1 | |
| SCHEMBL5226694 | 0.82 | KDM4E (0.43) | KMT2ANPC1KDM4EMAPK14GCGR | |
| SCHEMBL5221631 | 0.82 | SYK (0.42) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL5223501 | 0.82 | TRPA1 (0.44) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL5223017 | 0.81 | MAPT (0.39) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL5224995 | 0.81 | RPS6KA3 (0.37) | KMT2ANPC1RAB9AMAPTKDM4E | |
| SCHEMBL5227456 | 0.79 | MAPT (0.40) | KMT2ANPC1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |