Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225534 | 0.82 | PTGS2 (0.58) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5223948 | 0.81 | PTGS2 (0.56) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5207427 | 0.79 | PTGS2 (0.60) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5210195 | 0.74 | PTGS2 (0.82) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5229132 | 0.74 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8094773 | 0.72 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL5207593 | 0.72 | PTGS2 (0.69) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5224164 | 0.72 | ADORA1 (0.49) | — | |
| SCHEMBL7780024 | 0.71 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL3947751 | 0.71 | PTGS2 (0.61) | PTGS2PTGS1ABCC4ABCB11PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |