Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223948 | 0.87 | PTGS2 (0.56) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5223335 | 0.82 | PTGS2 (0.51) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5210195 | 0.79 | PTGS2 (0.82) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5229132 | 0.79 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL5207593 | 0.77 | PTGS2 (0.69) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL3947751 | 0.76 | PTGS2 (0.61) | PTGS2PTGS1ABCC4ABCB11PDE4D | |
| SCHEMBL5223261 | 0.76 | GSK3B (0.42) | — | |
| SCHEMBL5052857 | 0.75 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL5226664 | 0.74 | PTGS2 (0.48) | PTGS2PTGS1MAPK14 | |
| SCHEMBL6725659 | 0.74 | PTGS2 (1.00) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |