Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 4/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.55 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223407 | 1.00 | KDM5A (0.57) | KDM5AUSP30CTSLCTSBCTSK | |
| SCHEMBL31264267 | 0.91 | KMT2A (0.53) | KDM5AUSP30KDM4EGAAMEN1 | |
| SCHEMBL994466 | 0.87 | CTSL (0.63) | KDM5ACTSLCTSBCTSKMEN1 | |
| SCHEMBL3217188 | 0.84 | KDM5A (0.60) | KDM5ACTSLCTSBCTSKHTT | |
| SCHEMBL25400740 | 0.83 | CYP1A2 (0.57) | KDM5AUSP30CTSLCTSBCTSK | |
| SCHEMBL27100904 | 0.83 | CYP1A2 (0.57) | KDM5AUSP30CTSLCTSBCTSK | |
| SCHEMBL2787006 | 0.83 | KDM5A (0.43) | KDM5AUSP30CTSLCTSBCTSK | |
| SCHEMBL25403939 | 0.83 | CYP1A2 (0.57) | KDM5AUSP30CTSLCTSBCTSK | |
| SCHEMBL22394667 | 0.82 | KDM5A (0.42) | KDM5AUSP30KDM4EGAAHTT | |
| SCHEMBL29175675 | 0.82 | KDM5A (0.42) | KDM5AUSP30KDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861412-A1 | ADENOSINE DERIVATIVES HAVING A2A RECEPTOR ACTIVITY | Novartis AG (CH) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097260-A1 | ADENOSINE DERIVATIVES HAVING A2A RECEPTOR ACTIVITY | NOVARTIS AG (CH) | 2006-09-21 | — | — | WO | disclosed |