Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.66 |
| ▸ | CCKBR | P32239 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028988 | 0.90 | PDE5A (0.67) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL17760639 | 0.89 | PDE5A (0.71) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL1922143 | 0.89 | PDE5A (0.71) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL1196202 | 0.86 | PDE5A (0.53) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL21310005 | 0.84 | PDE5A (0.70) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL5029011 | 0.84 | PDE5A (0.70) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL4033799 | 0.84 | PDE5A (0.73) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL1197087 | 0.84 | PDE5A (0.73) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL1922013 | 0.84 | CCKBR (0.78) | PDE5ACCKBRKDM4EHSD17B10TSHR | |
| SCHEMBL1195763 | 0.84 | PDE5A (0.73) | PDE5ACCKBRKDM4EHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844046-A1 | NOVEL INDOLOPYRIDINES, BENZOFURANOPYRIDINES AND BENZOTHIENOPYRIDINES | Nycomed GmbH (DE) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006079645-A1 | NOVEL INDOLOPYRIDINES , BENZOFURANOPYRIDINES AND BENZOTHIENOPYRIDINES | NYCOMED GMBH (DE) | 2006-08-03 | — | — | WO | disclosed |