Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.44 |
| ▸ | CTSD | P07339 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223476 | 1.00 | BACE1 (0.44) | BACE1BACE2CTSDAPP | |
| SCHEMBL5223435 | 0.87 | BACE1 (0.42) | BACE1BACE2CTSD | |
| SCHEMBL4693114 | 0.87 | BACE1 (0.41) | BACE1BACE2CTSD | |
| SCHEMBL4693111 | 0.87 | BACE1 (0.41) | BACE1BACE2CTSD | |
| SCHEMBL5220282 | 0.83 | BACE1 (0.39) | BACE1BACE2CTSD | |
| SCHEMBL5220292 | 0.83 | BACE1 (0.39) | BACE1BACE2CTSD | |
| SCHEMBL5219195 | 0.82 | SIGMAR1 (0.43) | BACE1 | |
| SCHEMBL5219187 | 0.82 | SIGMAR1 (0.43) | BACE1 | |
| SCHEMBL5369028 | 0.80 | BACE1 (0.40) | BACE1BACE2CTSD | |
| SCHEMBL5223463 | 0.80 | OPRD1 (0.41) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |