Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5947547 | 0.93 | BCHE (0.59) | BCHESMN1; SMN2ALDH1A1L3MBTL1CYP2D6 | |
| SCHEMBL5222217 | 0.92 | BCHE (0.66) | BCHESMN1; SMN2ALDH1A1L3MBTL1THRB | |
| SCHEMBL2533896 | 0.92 | BCHE (0.57) | BCHESMN1; SMN2CHRM2ALDH1A1L3MBTL1 | |
| SCHEMBL5947343 | 0.88 | KDM4E (0.68) | BCHESMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL5947204 | 0.86 | BCHE (0.59) | BCHESMN1; SMN2CYP2D6KDM4E | |
| SCHEMBL5175955 | 0.86 | BCHE (0.53) | BCHESMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL5228081 | 0.84 | BCHE (0.68) | BCHESMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5947336 | 0.83 | BCHE (0.62) | BCHESMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2911574 | 0.83 | CHRM2 (0.70) | CHRM2CHRM1CHRM3CYP2D6 | |
| SCHEMBL5947350 | 0.83 | BCHE (0.72) | BCHECHRM2CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379239-B1 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | LILLY CO ELI (US) | 2007-09-12 | — | — | EP | claimed |
| EP-1379239-B1 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | LILLY CO ELI (US) | 2007-09-12 | — | — | EP | disclosed |