Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MC2R | Q01718 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2101417 | 1.00 | PTGDR2 (0.49) | PTGDR2ABCB11TSHRHTR2AHTR2C | |
| SCHEMBL12086409 | 0.91 | ABCB11 (0.48) | PTGDR2ABCB11TSHRHTR2AHTR2C | |
| SCHEMBL2101099 | 0.88 | MC2R (0.41) | PTGDR2ABCB11MC2RPROKR1ENPP2 | |
| SCHEMBL2103549 | 0.87 | PTGDR2 (0.54) | PTGDR2ABCB11TSHRHTR2AHTR2C | |
| SCHEMBL2099785 | 0.87 | PTGDR2 (0.60) | PTGDR2TSHRHTR2AHTR2CHTR2B | |
| SCHEMBL2099228 | 0.86 | TSHR (0.52) | PTGDR2ABCB11TSHRHTR2AHTR2C | |
| SCHEMBL2099806 | 0.83 | PTGDR2 (0.53) | PTGDR2TSHRLMNAPTGDRMAPT | |
| SCHEMBL2103319 | 0.80 | PTGER1 (0.48) | MC2RSCN9A | |
| SCHEMBL2102105 | 0.80 | ABCB11 (0.55) | PTGDR2ABCB11SLC6A9SCN9AMGLL | |
| SCHEMBL2102477 | 0.80 | ABCB11 (0.55) | PTGDR2ABCB11TSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784388-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2007-05-16 | — | — | EP | claimed |
| WO-2006021759-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2006-03-02 | — | — | WO | claimed |