Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11423248 | 0.87 | EPHX2 (0.51) | EPHX2TSHRMYCESR1ALOX15 | |
| SCHEMBL11424107 | 0.87 | EPHX2 (0.51) | EPHX2TSHRMYCESR1ALOX15 | |
| SCHEMBL15905718 | 0.85 | EPHX2 (0.50) | EPHX2TSHRMYCESR1ALOX15 | |
| SCHEMBL4549023 | 0.85 | ACE2 (0.53) | EPHX2TSHRMYCESR1ALOX15 | |
| SCHEMBL5518254 | 0.84 | NPSR1 (0.63) | EPHX2TSHRMYCESR1ALOX15 | |
| SCHEMBL6547934 | 0.84 | EPHX2 (0.36) | EPHX2HSD17B10RARBALDH1A1KDM4E | |
| SCHEMBL3708071 | 0.84 | HTR7 (0.53) | EPHX2TSHRMYCESR1ALOX15 | |
| SCHEMBL12226962 | 0.84 | PARP1 (0.43) | EPHX2TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL16302403 | 0.84 | EPHX2 (0.49) | EPHX2TSHRMYCESR1ALOX15 | |
| SCHEMBL27311828 | 0.84 | EPHX2 (0.49) | EPHX2TSHRMYCESR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309702-A1 | DYNAMIC INHIBITORS OF HEAT SHOCK PROTEIN 90 | UNIVERSITY OF KANSAS (US) | 2012-12-06 | — | — | US | disclosed |
| EP-1817306-A1 | TRIAZOLES AND THEIR USE AS BRADYKININ B1 RECEPTOR ANTAGONISTS | Amgen, Inc (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006044355-A1 | TRIAZOLES AND THEIR USE AS BRADYKININ B1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309702-A1 | DYNAMIC INHIBITORS OF HEAT SHOCK PROTEIN 90 | HSP90AA1, HSP90AB1, HSP90B1 | EPHX2 3772/4885TSHR 4116/4885MYC 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.