Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 3/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224145 | 1.00 | NR1H4 (0.41) | NR1H4SLC10A2KMT2AATMCTSD | |
| SCHEMBL5222572 | 0.95 | SLC10A2 (0.40) | NR1H4SLC10A2CTSDHDAC8NPC1 | |
| SCHEMBL5222581 | 0.95 | SLC10A2 (0.40) | NR1H4SLC10A2CTSDHDAC8NPC1 | |
| SCHEMBL14559683 | 0.89 | NR1H4 (0.43) | NR1H4SLC10A2KMT2AATMCTSD | |
| SCHEMBL5228158 | 0.88 | SLC10A2 (0.43) | SLC10A2KMT2AHDAC8NPC1RAB9A | |
| SCHEMBL5227015 | 0.86 | NR1H4 (0.39) | NR1H4SLC10A2KMT2AATMCTSD | |
| SCHEMBL5227007 | 0.86 | NR1H4 (0.39) | NR1H4SLC10A2KMT2AATMCTSD | |
| SCHEMBL5225650 | 0.85 | SLC10A2 (0.40) | SLC10A2KMT2AHDAC8NPC1RAB9A | |
| SCHEMBL5226995 | 0.84 | NR1H4 (0.41) | NR1H4SLC10A2KMT2AATMCTSD | |
| SCHEMBL5391816 | 0.84 | NR1H4 (0.41) | NR1H4SLC10A2KMT2AATMCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345918-B1 | 1,5 BENZOTHIAZEPINES AND THEIR USE AS ANTIHYPERLIPIDEMICS | ASTRAZENECA AB (SE) | 2007-04-18 | — | — | EP | disclosed |