Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227007 | 1.00 | NR1H4 (0.39) | NR1H4KMT2AMEN1LMNACTSD | |
| SCHEMBL5222581 | 0.91 | SLC10A2 (0.40) | NR1H4CTSDNPC1RAB9ASLC10A2 | |
| SCHEMBL5222572 | 0.91 | SLC10A2 (0.40) | NR1H4CTSDNPC1RAB9ASLC10A2 | |
| SCHEMBL5391816 | 0.89 | NR1H4 (0.41) | NR1H4KMT2AMEN1CTSDALDH1A1 | |
| SCHEMBL5226995 | 0.89 | NR1H4 (0.41) | NR1H4KMT2AMEN1CTSDALDH1A1 | |
| SCHEMBL5224147 | 0.86 | NR1H4 (0.41) | NR1H4KMT2ACTSDNPC1RAB9A | |
| SCHEMBL5224145 | 0.86 | NR1H4 (0.41) | NR1H4KMT2ACTSDNPC1RAB9A | |
| SCHEMBL14559683 | 0.84 | NR1H4 (0.43) | NR1H4KMT2AMEN1CTSDNPC1 | |
| SCHEMBL14559705 | 0.79 | NR1H4 (0.48) | NR1H4SLC10A2POLB | |
| SCHEMBL14559720 | 0.79 | NR1H4 (0.47) | NR1H4KMT2AMEN1SLC10A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345918-B1 | 1,5 BENZOTHIAZEPINES AND THEIR USE AS ANTIHYPERLIPIDEMICS | ASTRAZENECA AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| US-7192945-B2 | Benzothiazepine derivatives | ASTRAZENECA AB (SE) | 2007-03-20 | — | — | US | disclosed |