Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.46 |
| ▸ | GLS | O94925 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15602026 | 0.87 | LMNA (0.57) | LMNAMPOHCRTR1HCRTR2GLS | |
| SCHEMBL1793682 | 0.87 | LMNA (0.78) | LMNAMPOHCRTR1HCRTR2GLS | |
| Hydrochloric Acid SCHEMBL5656437 | 0.85 | LMNA (0.76) | LMNAMPOHCRTR1HCRTR2GLS | |
| SCHEMBL321235 | 0.84 | LMNA (0.55) | LMNAMPOHCRTR1HCRTR2GLS | |
| SCHEMBL17629558 | 0.80 | LMNA (0.57) | LMNAMPOHCRTR1HCRTR2GLS | |
| SCHEMBL27778663 | 0.80 | LMNA (0.57) | LMNAMPOHCRTR1HCRTR2GLS | |
| SCHEMBL4117917 | 0.80 | LMNA (0.57) | LMNAMPOHCRTR1HCRTR2GLS | |
| SCHEMBL28079351 | 0.80 | LMNA (0.61) | LMNAMPOHCRTR1HCRTR2GLS | |
| SCHEMBL327273 | 0.80 | LMNA (0.57) | LMNAMPOHCRTR1HCRTR2GLS | |
| SCHEMBL5017674 | 0.79 | LMNA (0.57) | LMNAMPOHCRTR1HCRTR2GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581516-A4 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | BRISTOL MYERS SQUIBB CO (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1581516-A2 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047744-A2 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |