Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.33 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197798 | 0.79 | PDGFRB (0.46) | PDGFRBPDGFRA | |
| SCHEMBL197931 | 0.78 | EGFR (0.40) | EHMT2EHMT1 | |
| SCHEMBL199314 | 0.74 | EHMT2 (0.60) | EHMT2EHMT1 | |
| SCHEMBL198154 | 0.74 | KMT5A (0.43) | EHMT2ENPP1 | |
| SCHEMBL199299 | 0.73 | EHMT2 (0.51) | EHMT2EHMT1 | |
| SCHEMBL197702 | 0.72 | KDM4E (0.53) | EHMT2EHMT1HSD17B10 | |
| SCHEMBL199128 | 0.71 | AXL (0.52) | EHMT2EHMT1 | |
| SCHEMBL197930 | 0.66 | PDGFRB (0.33) | PDGFRBPDGFRA | |
| SCHEMBL16673289 | 0.62 | L3MBTL1 (0.37) | — | |
| SCHEMBL16673303 | 0.62 | L3MBTL1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827434-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | Amgen Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006060318-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC. (US) | 2006-06-08 | — | — | WO | disclosed |