Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | INMT | O95050 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224501 | 0.88 | POLB (0.36) | POLBINMTACHE | |
| SCHEMBL5222432 | 0.87 | TP53 (0.38) | POLBTP53MAPT | |
| SCHEMBL5219323 | 0.77 | POLB (0.39) | POLBTP53MAPTPTGER1 | |
| SCHEMBL5222429 | 0.76 | SMN1; SMN2 (0.34) | TP53MAPT | |
| SCHEMBL5219490 | 0.74 | BACE1 (0.50) | POLBTP53MAPTCTSDBACE1 | |
| SCHEMBL5218338 | 0.74 | POLB (0.46) | POLBTP53MAPTPTGER1CTSD | |
| SCHEMBL5224403 | 0.73 | POLB (0.45) | POLBTP53PTGER1CTSDBACE1 | |
| SCHEMBL5217621 | 0.73 | POLB (0.43) | POLBTP53MAPTPTGER1CTSD | |
| SCHEMBL6184274 | 0.72 | POLB (0.39) | POLBTP53 | |
| SCHEMBL5218650 | 0.71 | POLB (0.44) | POLBTP53CTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |