Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | INMT | O95050 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224504 | 0.88 | POLB (0.46) | POLBINMTACHE | |
| SCHEMBL5222429 | 0.87 | SMN1; SMN2 (0.34) | ALDH1A1KDM4ETSHRHSD17B10 | |
| SCHEMBL5219330 | 0.77 | POLB (0.30) | POLB | |
| SCHEMBL5222432 | 0.76 | TP53 (0.38) | POLBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5224401 | 0.73 | POLB (0.35) | POLB | |
| SCHEMBL5219484 | 0.73 | BACE1 (0.44) | POLBALDH1A1KDM4EHPGD | |
| SCHEMBL6226616 | 0.73 | POLB (0.33) | POLB | |
| SCHEMBL5217639 | 0.73 | CTSD (0.37) | POLBHPGD | |
| SCHEMBL6184270 | 0.72 | UCHL1 (0.39) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5223926 | 0.71 | CTSD (0.36) | POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |