Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224401 | 0.88 | POLB (0.35) | POLBTP53HCAR3 | |
| SCHEMBL5219941 | 0.88 | POLB (0.37) | POLBCTSDBACE1BACE2TP53 | |
| SCHEMBL5219490 | 0.80 | BACE1 (0.50) | POLBCTSDBACE1BACE2TP53 | |
| SCHEMBL5219935 | 0.76 | ALDH1A1 (0.34) | — | |
| SCHEMBL5219825 | 0.76 | BACE1 (0.47) | POLBCTSDBACE1BACE2TP53 | |
| SCHEMBL5224504 | 0.73 | POLB (0.46) | POLBCTSDBACE1BACE2TP53 | |
| SCHEMBL5217621 | 0.72 | POLB (0.43) | POLBCTSDBACE1BACE2TP53 | |
| SCHEMBL5218338 | 0.70 | POLB (0.46) | POLBCTSDBACE1BACE2TP53 | |
| SCHEMBL5223919 | 0.70 | POLB (0.44) | POLBCTSDBACE1BACE2TP53 | |
| SCHEMBL5218650 | 0.70 | POLB (0.44) | POLBCTSDBACE1BACE2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |