Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 11/20 | 0.49 |
| ▸ | LCK | P06239 | 8/20 | 0.49 |
| ▸ | KDR | P35968 | 8/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222484 | 0.78 | RIPK2 (0.45) | RIPK2LCKKDRTGFBR1CSNK1D | |
| SCHEMBL5227887 | 0.76 | RIPK2 (0.53) | RIPK2LCKKDRTGFBR1CSNK1D | |
| SCHEMBL29598464 | 0.73 | HDAC6 (0.46) | RIPK2LCKKDRTGFBR1 | |
| SCHEMBL28777612 | 0.73 | PARP1 (0.39) | SYKJAK2 | |
| SCHEMBL4504523 | 0.73 | JAK2 (0.49) | JAK2 | |
| SCHEMBL23539749 | 0.72 | DYRK1A (0.44) | TGFBR1 | |
| SCHEMBL3308095 | 0.72 | PIK3CA (0.53) | RIPK2LCKKDRTGFBR1 | |
| SCHEMBL30775503 | 0.71 | SYK (0.41) | TGFBR1SYKJAK2 | |
| SCHEMBL29207870 | 0.71 | SYK (0.41) | TGFBR1SYKJAK2 | |
| SCHEMBL5225861 | 0.71 | BCAT2 (0.49) | RIPK2LCKKDRTGFBR1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |