Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | LGMN | Q99538 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29800136 | 0.73 | IKBKB (0.44) | TGFBR1MEN1KMT2A | |
| SCHEMBL29026149 | 0.73 | JAK2 (0.43) | TGFBR1POLBKDM4E | |
| SCHEMBL5224565 | 0.72 | RIPK2 (0.49) | TGFBR1 | |
| SCHEMBL30627270 | 0.72 | ABL1 (0.36) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL945449 | 0.71 | HSP90AA1 (0.52) | MTOR | |
| SCHEMBL29598822 | 0.71 | HDAC6 (0.46) | — | |
| SCHEMBL5341775 | 0.71 | BCAT2 (0.49) | DYRK1AVRK1TGFBR1NPC1RAB9A | |
| SCHEMBL30627238 | 0.71 | ABL1 (0.35) | PIK3CAPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL30627079 | 0.71 | TRPA1 (0.53) | DYRK1A | |
| SCHEMBL13237237 | 0.70 | TGFBR1 (0.52) | DYRK1ATGFBR1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076520-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127190-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |