Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5122976 | 0.82 | MAPK14 (0.62) | MAPK14LCKMAP2K1MAPK11HSPB1 | |
| SCHEMBL14078280 | 0.74 | MAPK14 (0.66) | MAPK14LCKMAP2K1MAPK11HSPB1 | |
| SCHEMBL5220199 | 0.73 | MAPK14 (0.50) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL5221091 | 0.73 | MAPK14 (0.64) | MAPK14LCKMAP2K1CSF1R | |
| SCHEMBL5216405 | 0.72 | MAPK14 (0.57) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL5113564 | 0.71 | MAPK14 (0.61) | MAPK14LCKMAP2K1MAPK11CSF1R | |
| SCHEMBL4856439 | 0.69 | MAPK14 (1.00) | MAPK14LCKMAPK11 | |
| SCHEMBL14078304 | 0.69 | MAPK14 (0.71) | MAPK14LCKMAP2K1MAPK11CSF1R | |
| SCHEMBL5122607 | 0.68 | MAPK14 (0.60) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL4864546 | 0.68 | MAPK14 (0.78) | MAPK14LCKMAP2K1MAPK11CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | claimed |