Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3072596 | 0.81 | MAPK14 (0.82) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL5456029 | 0.79 | MAPK14 (0.78) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL6032004 | 0.79 | MAPK14 (0.59) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL5220199 | 0.78 | MAPK14 (0.50) | MAPK14MAP2K1MAPK11SMN1; SMN2 | |
| SCHEMBL5220245 | 0.77 | MAPK14 (0.61) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL5465001 | 0.75 | MAPK14 (0.72) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL10089430 | 0.75 | FAAH (0.67) | FAAH | |
| SCHEMBL5461337 | 0.74 | MAPK14 (0.71) | MAPK14MAP2K1MAPK11 | |
| SCHEMBL5221091 | 0.73 | MAPK14 (0.64) | MAPK14MAP2K1 | |
| SCHEMBL5118009 | 0.72 | MAPK14 (1.00) | MAPK14MAP2K1MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | claimed |