Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116871 | 0.83 | MAPK14 (0.65) | MAPK14MAPK11MAP2K1SMN1; SMN2 | |
| SCHEMBL5217308 | 0.78 | MAPK14 (0.48) | MAPK14MAPK11MAP2K1NPC1RAB9A | |
| SCHEMBL5216405 | 0.78 | MAPK14 (0.57) | MAPK14MAPK11MAP2K1SMN1; SMN2 | |
| SCHEMBL5117599 | 0.75 | MAPK14 (0.64) | MAPK14MAPK11MAP2K1SMN1; SMN2 | |
| SCHEMBL5224749 | 0.73 | MAPK14 (0.53) | MAPK14MAPK11MAP2K1 | |
| SCHEMBL5221091 | 0.72 | MAPK14 (0.64) | MAPK14MAP2K1 | |
| SCHEMBL5220245 | 0.70 | MAPK14 (0.61) | MAPK14MAPK11MAP2K1 | |
| SCHEMBL5114250 | 0.68 | MAPK14 (0.64) | MAPK14MAPTMAPK11MAP2K1NPC1 | |
| SCHEMBL5122607 | 0.68 | MAPK14 (0.60) | MAPK14MAPK11MAP2K1NPC1RAB9A | |
| SCHEMBL5898946 | 0.67 | MAPK14 (0.60) | MAPK14RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-B1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | claimed |