Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226008 | 0.83 | RAB9A (0.44) | CHRM1CHRM2RAB9ATHRBATM | |
| SCHEMBL22852237 | 0.83 | MAPK1 (0.53) | CHRM1CHRM2RAB9ATP53TDP1 | |
| SCHEMBL5219039 | 0.82 | RAB9A (0.43) | CHRM1CHRM2RAB9ATHRBATM | |
| SCHEMBL5221871 | 0.81 | RAB9A (0.43) | CHRM1CHRM2RAB9ATHRBATM | |
| SCHEMBL5217684 | 0.81 | RAB9A (0.43) | CHRM1CHRM2RAB9ATHRBATM | |
| SCHEMBL5221770 | 0.80 | RAB9A (0.42) | RAB9ACHRM4GAASMN1; SMN2 | |
| SCHEMBL10089204 | 0.78 | RAB9A (0.48) | CHRM1CHRM2RAB9ATHRBATM | |
| SCHEMBL1693216 | 0.78 | RAB9A (0.48) | CHRM1CHRM2RAB9ACYP3A4THRB | |
| SCHEMBL4977215 | 0.78 | RAB9A (0.48) | CHRM1CHRM2RAB9ATHRBATM | |
| SCHEMBL4036153 | 0.78 | HPGD (0.50) | CHRM1KDM4EHRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789410-A1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006029906-A1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2006-03-23 | — | — | WO | disclosed |