Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219039 | 0.87 | RAB9A (0.43) | RAB9AGAANOS3NOS2GPR119 | |
| SCHEMBL5217684 | 0.85 | RAB9A (0.43) | RAB9AGAANOS3NOS2GPR119 | |
| SCHEMBL5221871 | 0.85 | RAB9A (0.43) | RAB9AGAANOS3NOS2GPR119 | |
| SCHEMBL5221770 | 0.84 | RAB9A (0.42) | RAB9AGAANOS3NOS2GPR119 | |
| SCHEMBL5225927 | 0.83 | CHRM1 (0.46) | RAB9AGAAL3MBTL1THRBATM | |
| SCHEMBL1693216 | 0.83 | RAB9A (0.48) | RAB9AGAANOS3NOS2GPR119 | |
| SCHEMBL10089204 | 0.83 | RAB9A (0.48) | RAB9AGAANOS3NOS2GPR119 | |
| SCHEMBL4977215 | 0.83 | RAB9A (0.48) | RAB9AGAANOS3NOS2GPR119 | |
| SCHEMBL8921640 | 0.82 | RAB9A (0.45) | RAB9AHRH3KITHRH2HRH1 | |
| SCHEMBL2894884 | 0.81 | TPSAB1 (0.47) | RAB9AGAANOS3NOS2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789410-A1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006029906-A1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2006-03-23 | — | — | WO | disclosed |