Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224914 | 0.90 | PRMT5 (0.41) | ACSL1PRMT5WDR77ALDH1A1KDM4E | |
| SCHEMBL5228451 | 0.90 | PRMT5 (0.41) | ACSL1PRMT5WDR77ALDH1A1KDM4E | |
| SCHEMBL4861528 | 0.83 | CYP3A4 (0.45) | CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5223653 | 0.75 | HTR1A (0.40) | PRMT5WDR77ALDH1A1KDM4ETLR9 | |
| SCHEMBL5227545 | 0.75 | SMN1; SMN2 (0.43) | ALDH1A1KDM4ETLR9CYP1A2CYP3A4 | |
| SCHEMBL6206447 | 0.75 | SMN1; SMN2 (0.43) | ALDH1A1KDM4ETLR9CYP1A2CYP3A4 | |
| SCHEMBL4863473 | 0.74 | CYP3A4 (0.48) | CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4865782 | 0.74 | CYP3A4 (0.48) | CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5901370 | 0.74 | PKM (0.49) | ACSL1ALDH1A1KDM4ETLR9CHRNA7 | |
| SCHEMBL5965265 | 0.74 | PKM (0.49) | ACSL1ALDH1A1KDM4ETLR9CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806346-A1 | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | CV THERAPEUTICS, INC. (US) | 2007-07-11 | — | — | EP | disclosed |