Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.55 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226068 | 0.92 | TRPV1 (0.52) | TRPV1ACSS2CYP1A2CYP2C19 | |
| SCHEMBL14554346 | 0.81 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL5229878 | 0.76 | CYP17A1 (0.35) | TRPV1CYP1A2CYP2C19 | |
| SCHEMBL5128882 | 0.73 | TRPV1 (0.43) | TRPV1ACSS2 | |
| SCHEMBL30466627 | 0.73 | DYRK1A (0.49) | TRPV1 | |
| SCHEMBL21954259 | 0.73 | DYRK1A (0.49) | TRPV1 | |
| SCHEMBL5126037 | 0.73 | TRPV1 (0.77) | TRPV1 | |
| SCHEMBL4940734 | 0.72 | CLK1 (0.52) | CYP1A2CYP2C19 | |
| SCHEMBL1848638 | 0.72 | TRPV1 (0.52) | TRPV1 | |
| SCHEMBL5383433 | 0.72 | MEN1 (0.61) | ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | claimed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | claimed |
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |
| EP-1622884-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096784-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | disclosed |