Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.34 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 6/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229881 | 0.93 | CYP17A1 (0.35) | CYP17A1METAP1CYP1A2CYP2C19KCNQ4 | |
| SCHEMBL18180255 | 0.82 | NPC1 (0.39) | CYP17A1METAP1LCKBRAFLMNA | |
| SCHEMBL5226064 | 0.76 | TRPV1 (0.55) | CYP1A2CYP2C19TRPV1 | |
| SCHEMBL5122450 | 0.74 | CYP17A1 (0.32) | CYP17A1METAP1KCNQ4KCNQ5BRAF | |
| SCHEMBL5226068 | 0.68 | TRPV1 (0.52) | CYP1A2CYP2C19TRPV1 | |
| SCHEMBL29069807 | 0.67 | CYP17A1 (0.41) | CYP17A1METAP1KCNQ4KCNQ5RXFP1 | |
| SCHEMBL10187654 | 0.66 | CYP17A1 (0.43) | CYP17A1METAP1KCNQ4KCNQ5LCK | |
| SCHEMBL28707071 | 0.66 | CYP17A1 (0.43) | CYP17A1METAP1KCNQ4KCNQ5RXFP1 | |
| SCHEMBL30126587 | 0.66 | CYP17A1 (0.39) | CYP17A1METAP1CYP2C19KCNQ4KCNQ5 | |
| SCHEMBL30466622 | 0.66 | GAA (0.46) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |