Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4981793 | 0.78 | CSNK1D (0.56) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4981850 | 0.77 | ALDH1A1 (0.51) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL209281 | 0.75 | ALDH1A1 (0.54) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL4976756 | 0.75 | HDAC6 (0.57) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL4976545 | 0.74 | NPC1 (0.50) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5224395 | 0.74 | KMT2A (0.40) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4978405 | 0.73 | SMN1; SMN2 (0.50) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4977099 | 0.72 | ALDH1A1 (0.54) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14263307 | 0.72 | KMT2A (0.38) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4978799 | 0.71 | NPC1 (0.60) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |