Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224395 | 0.88 | KMT2A (0.40) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL14263321 | 0.85 | BRD4 (0.34) | NPC1MAPTALDH1A1KDM4EHTT | |
| SCHEMBL4978681 | 0.81 | MAPT (0.41) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL4976760 | 0.81 | ALDH1A1 (0.44) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL4978503 | 0.81 | KMT2A (0.42) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL4978620 | 0.79 | MAPT (0.50) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL14263381 | 0.77 | BRAF (0.36) | KDM4E | |
| SCHEMBL5226700 | 0.77 | SLC2A1 (0.33) | CYP2D6 | |
| SCHEMBL14274184 | 0.72 | BRD4 (0.33) | — | |
| SCHEMBL5226459 | 0.72 | KMT2A (0.47) | KMT2ASMN1; SMN2MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |