SCHEMBL5226679

SCHEMBL5226679

CN1C(=O)OC2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)CC21Cc1cccnc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 18/20 0.55
UGCG Q16739 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6311781 0.89 GHSR (0.55) GHSRUGCG
Hydrochloric Acid SCHEMBL5230923 0.88 GHSR (0.54) GHSRUGCG
SCHEMBL5224906 0.81 GHSR (0.55) GHSRUGCG
SCHEMBL5231097 0.79 GHSR (0.44) GHSRUGCG
SCHEMBL5226528 0.77 GHSR (0.58) GHSR
SCHEMBL5227926 0.76 GHSR (0.48) GHSR
SCHEMBL5228678 0.76 GHSR (0.51) GHSRUGCG
SCHEMBL14056869 0.75 GHSR (0.52) GHSRUGCG
SCHEMBL14056867 0.75 GHSR (0.52) GHSRUGCG
SCHEMBL14058679 0.75 GHSR (0.53) GHSRUGCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001970-B1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER (US) 2007-03-07 EP claimed
US-6924280-B2 Dipeptide derivatives PFIZER INC. (US) 2005-08-02 US claimed
US-20040009984-A1 Increasing levels of endogenous growth hormone, especially treating osterporosis, aging frailty or congestive heart failure CARPINO PHILIP ALBERT (US) 2004-01-15 US claimed
US-20040006063-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2004-01-08 US claimed
US-20030216399-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2003-11-20 US claimed
US-20020065284-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-05-30 US claimed
US-20020042415-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-04-11 US claimed
US-20020002165-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-01-03 US claimed
US-20010041703-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2001-11-15 US claimed
EP-1001970-B1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER (US) 2007-03-07 EP disclosed
US-6953791-B2 Dipeptide derivatives PFIZER, INC. (US) 2005-10-11 US disclosed
US-6951850-B2 Dipeptide derivatives PFIZER, INC. (US) 2005-10-04 US disclosed
US-6924280-B2 Dipeptide derivatives PFIZER INC. (US) 2005-08-02 US disclosed
US-RE38524-E1 Dipeptide derivatives as growth hormone secretagogues PFIZER INC. 2004-06-01 US disclosed
US-6432945-B1 Dipeptide derivatives PFIZER INC. 2002-08-13 US disclosed
US-6429313-B2 Dipeptide derivatives PFIZER INC. 2002-08-06 US disclosed
US-20020065284-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-05-30 US disclosed
US-20020042415-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-04-11 US disclosed
US-20020002165-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-01-03 US disclosed
US-20010041703-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2001-11-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040009984-A1 Increasing levels of endogenous growth hormone, especially treating osterporosis, aging frailty or congestive heart failure GHSR, GHRHR, GIPR GHSR 1/4885UGCG 1722/4885
US-20020042415-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885UGCG 2325/4885
US-20010041703-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885UGCG 1989/4885
US-20020002165-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885UGCG 2325/4885
US-20040006063-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885UGCG 2340/4885
US-20030216399-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885UGCG 2325/4885
US-20020065284-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885UGCG 2325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.