Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | FABP1 | P07148 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223605 | 0.84 | HSP90AB1 (0.43) | MAPK14CNR2PDE4AOPRM1OPRL1 | |
| SCHEMBL5225622 | 0.80 | MAPK14 (0.38) | MAPK14ALDH1A1MAPK1MEN1STAT3 | |
| SCHEMBL5225468 | 0.79 | MAPK14 (0.60) | MAPK14FABP1 | |
| SCHEMBL5229775 | 0.79 | MAPK14 (0.41) | MAPK14TLR8BRD4 | |
| SCHEMBL5230882 | 0.79 | ALDH1A1 (0.33) | MAPK14ABL1ALDH1A1MAPK1MEN1 | |
| SCHEMBL5227756 | 0.79 | MAPK14 (0.54) | MAPK14PTGS2FABP1 | |
| SCHEMBL3282205 | 0.79 | MAPK14 (0.59) | MAPK14FABP1 | |
| SCHEMBL5229428 | 0.78 | MAPK14 (0.38) | MAPK14ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL5230029 | 0.78 | RPS6KA6 (0.31) | MAPK14PDE4AALDH1A1STAT3SMN1; SMN2 | |
| SCHEMBL5231774 | 0.78 | ALDH1A1 (0.35) | MAPK14ALDH1A1MAPK1MEN1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1842851-A2 | Novel compounds | Smithkline Beecham Corporation (US) | 2007-10-10 | — | — | EP | disclosed |
| EP-1265900-B1 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO 4,5-D|PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 2007-05-16 | — | — | EP | disclosed |