Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.59 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2891699 | 0.87 | RIPK1 (0.62) | RIPK1CSNK1DCSNK1G2MAPTSAE1 | |
| SCHEMBL17488031 | 0.81 | RIPK1 (0.51) | RIPK1MAPTPOLBMEN1KMT2A | |
| SCHEMBL17488032 | 0.81 | RAB9A (0.67) | MAPTMEN1KMT2AIRAK4ALDH1A1 | |
| SCHEMBL17488168 | 0.80 | RIPK1 (0.55) | RIPK1MAPTMEN1KMT2AIRAK4 | |
| SCHEMBL1701289 | 0.79 | RIPK1 (0.71) | RIPK1CSNK1DCSNK1G2MAPTHDAC11 | |
| SCHEMBL19329541 | 0.78 | RIPK1 (0.54) | RIPK1CSNK1DCSNK1G2MAPTPOLB | |
| SCHEMBL3183535 | 0.77 | MAPT (0.66) | MAPTPOLBSAE1UBA2MEN1 | |
| SCHEMBL4446981 | 0.77 | NPC1 (0.59) | RIPK1CSNK1DCSNK1G2MAPTHDAC11 | |
| SCHEMBL2891701 | 0.77 | RIPK1 (0.77) | RIPK1CSNK1DCSNK1G2MAPTPOLB | |
| SCHEMBL20685316 | 0.76 | SMN1; SMN2 (0.43) | RIPK1CSNK1DCSNK1G2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |