Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980450 | 0.86 | BRAF (0.46) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL588578 | 0.83 | RAB9A (0.52) | NPC1RAB9AMAPTPOLBTP53 | |
| SCHEMBL14263278 | 0.80 | CDC7 (0.47) | BRAFNPC1RAB9AKDR | |
| SCHEMBL5228478 | 0.80 | NPC1 (0.41) | BRAFNPC1RAB9AMAPTPOLB | |
| SCHEMBL5225357 | 0.80 | NPC1 (0.40) | BRAFNPC1RAB9ALCKFYN | |
| SCHEMBL15473901 | 0.80 | RHEB (0.42) | NPC1RAB9APOLBTP53SMN1; SMN2 | |
| SCHEMBL17745103 | 0.77 | KDM4E (0.47) | NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5226590 | 0.77 | GRM5 (0.38) | BRAFNPC1RAB9AMAPTPOLB | |
| SCHEMBL17260987 | 0.76 | AURKA (0.50) | BRAFNPC1RAB9AKITKDR | |
| SCHEMBL5227351 | 0.76 | KDR (0.44) | BRAFNPC1RAB9APDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |