Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227301 | 0.84 | KDM1A (0.46) | ALDH1A1HSD17B2RIPK1MEN1KMT2A | |
| SCHEMBL3345083 | 0.82 | PSEN1 (0.49) | — | |
| SCHEMBL3346480 | 0.81 | PSEN1 (0.38) | SOAT1HSD17B2XIAP | |
| SCHEMBL3346473 | 0.81 | PSEN1 (0.38) | SOAT1HSD17B2XIAP | |
| SCHEMBL3343323 | 0.81 | SOAT1 (0.35) | ALDH1A1SOAT1HSD17B2MEN1KMT2A | |
| SCHEMBL3343463 | 0.77 | ALDH1A1 (0.40) | ALDH1A1MAPK1HSD17B2MEN1KMT2A | |
| SCHEMBL14260860 | 0.77 | ALDH1A1 (0.53) | ALDH1A1RECQLMEN1KMT2A | |
| SCHEMBL4117171 | 0.76 | TP53 (0.39) | ALDH1A1MAPK1HSD17B2GAA | |
| SCHEMBL8338572 | 0.76 | KDM4E (0.40) | ALDH1A1MAPK1RECQLHSD17B2AKR1B1 | |
| SCHEMBL14260858 | 0.76 | KDM4E (0.40) | ALDH1A1MAPK1RECQLHSD17B2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |