Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232715 | 0.83 | CYP1A2 (0.39) | CYP1A2CYP2C19MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL617951 | 0.67 | NPC1 (0.44) | CYP1A2CYP2C19MAPTSMN1; SMN2LMNA | |
| SCHEMBL27453303 | 0.63 | MEN1 (0.56) | MAPTSMN1; SMN2AKR1B1LMNAHPGD | |
| SCHEMBL4940739 | 0.62 | CYP1A2 (0.49) | CYP1A2CYP2C19MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL8858952 | 0.62 | AKR1B1 (0.46) | CYP2C19MAPTSMN1; SMN2AKR1B1LMNA | |
| SCHEMBL28366866 | 0.60 | CYP1A2 (0.50) | CYP1A2CYP2C19MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL10514966 | 0.60 | MEN1 (0.51) | MAPTSMN1; SMN2AKR1B1LMNAHPGD | |
| SCHEMBL20511910 | 0.59 | CYP1A2 (0.73) | CYP1A2CYP2C19MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL11865568 | 0.59 | NPC1 (0.43) | MAPTL3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL11496696 | 0.58 | LMNA (0.53) | MAPTL3MBTL1SMN1; SMN2LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |
| EP-1622884-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096784-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | disclosed |