Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8858938 | 0.81 | AKR1B1 (0.46) | AKR1B1TDP1LMNAMEN1KMT2A | |
| SCHEMBL8858951 | 0.75 | AKR1B1 (0.47) | AKR1B1TDP1LMNAMEN1KMT2A | |
| SCHEMBL8858925 | 0.71 | AKR1A1 (0.54) | AKR1B1 | |
| SCHEMBL28638703 | 0.69 | HTT (0.61) | TDP1LMNAKMT2ACYP2C19MAPT | |
| SCHEMBL8858909 | 0.69 | AKR1B1 (0.42) | AKR1B1TDP1LMNAMEN1KMT2A | |
| SCHEMBL137486 | 0.69 | TDP1 (0.83) | TDP1LMNAKMT2AESR1ESR2 | |
| SCHEMBL547137 | 0.67 | TDP1 (0.79) | TDP1LMNAKMT2AESR1ESR2 | |
| SCHEMBL28286830 | 0.67 | TDP1 (0.79) | TDP1LMNAKMT2AESR1ESR2 | |
| SCHEMBL13292516 | 0.67 | TDP1 (0.79) | TDP1LMNAKMT2AESR1ESR2 | |
| SCHEMBL16217656 | 0.67 | TDP1 (0.79) | TDP1LMNAKMT2AESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700819-A | ALDOSE REDUCTASE ENZYME INHIBITOR | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 1997-12-23 | — | — | US | disclosed |