Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.50 |
| ▸ | HTR3A | P46098 | 4/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228643 | 0.82 | CHRNA7 (0.52) | CHRNA7HTR3AHTR3EHTR3BCHRNB4 | |
| SCHEMBL6100330 | 0.81 | SSTR3 (0.47) | — | |
| Hydrochloric Acid SCHEMBL7126791 | 0.81 | SSTR3 (0.46) | — | |
| SCHEMBL6479894 | 0.80 | CHRNA7 (0.47) | CHRNA7HTR3AHTR3EHTR3BCHRNB4 | |
| SCHEMBL6478750 | 0.80 | CHRNA7 (0.49) | CHRNA7HTR3AHTR3EHTR3BCHRNB4 | |
| SCHEMBL5226666 | 0.80 | CHRNA7 (0.55) | CHRNA7HTR3AHTR3EHTR3BCHRNB4 | |
| SCHEMBL7121745 | 0.80 | CHRNB2 (0.40) | CHRNA7 | |
| SCHEMBL6098344 | 0.80 | CHRNB4 (0.39) | CHRNA7HTR3AHTR3EHTR3BCHRNB4 | |
| SCHEMBL14608938 | 0.79 | HDAC6 (0.44) | CHRNB4CHRNA3GAA | |
| SCHEMBL7121130 | 0.79 | SLC6A3 (0.40) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425286-B1 | SUBSTITUTED 7-AZA-[2.2.1]BICYCLOHEPTANES FOR THE TREATMENT OF DISEASES | PHARMACIA & UPJOHN CO LLC (US) | 2007-02-28 | — | — | EP | claimed |