Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL509399 | 0.80 | MAPT (0.36) | KEAP1NFE2L2KLKB1MAPTPTGDR2 | |
| SCHEMBL5227599 | 0.74 | ADCY10 (0.33) | KLKB1MAPTPTGDR2 | |
| SCHEMBL5233666 | 0.74 | PTGDR2 (0.33) | KLKB1MAPTPTGDR2 | |
| SCHEMBL10285156 | 0.73 | DRD2 (0.34) | KLKB1MAPTPTGDR2 | |
| SCHEMBL509217 | 0.73 | PTGDR2 (0.38) | MAPTPTGDR2CARM1PRMT6PPARG | |
| SCHEMBL5556430 | 0.70 | ADCY10 (0.34) | KLKB1MAPT | |
| SCHEMBL14540663 | 0.67 | MAPT (0.36) | KLKB1MAPTPTGDR2 | |
| SCHEMBL508683 | 0.66 | PTGDR2 (0.46) | MAPTPTGDR2 | |
| SCHEMBL509867 | 0.65 | MAPT (0.40) | MAPTPTGDR2CARM1PRMT6 | |
| SCHEMBL10250143 | 0.65 | PTGDR2 (0.40) | MAPTMAPK1PTGDR2MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377556-B1 | PYRAZOLE DERIVATIVES FOR TREATING HIV | PFIZER LTD (GB) | 2007-04-04 | — | — | EP | claimed |