Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226476 | 0.99 | HTR6 (0.51) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL5227156 | 0.90 | HTR6 (0.48) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL5232161 | 0.87 | HTR6 (0.53) | HTR6CYP3A4CYP2D6L3MBTL1 | |
| SCHEMBL5227430 | 0.86 | HTR6 (0.53) | HTR6CYP3A4CYP2D6L3MBTL1 | |
| SCHEMBL5228736 | 0.84 | HTR6 (0.49) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL5231031 | 0.80 | HTR6 (0.57) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL946708 | 0.75 | HTR6 (0.56) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL946237 | 0.74 | HTR6 (0.81) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| SCHEMBL5231136 | 0.74 | HTR6 (0.47) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C | |
| Hydrochloric Acid SCHEMBL947681 | 0.73 | HTR6 (0.79) | HTR6CYP3A4ADRA2ACYP2D6ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1523486-B1 | TETRACYCLIC ARYLSULFONYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY | SUVEN LIFE SCIENCES LTD (IN) | 2007-11-07 | — | — | EP | disclosed |