Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229171 | 0.88 | GSK3B (0.42) | GSK3BHDAC1EPHX1MAPK1ROCK2 | |
| SCHEMBL5234548 | 0.88 | MAPT (0.49) | GSK3BNAMPTEPHX1MAPK1ROCK2 | |
| SCHEMBL5243973 | 0.84 | TSHR (0.48) | GSK3BP2RX7EPHX1MAPK1ROCK2 | |
| SCHEMBL5232027 | 0.82 | EPHX1 (0.51) | GSK3BNAMPTEPHX1MAPK1ROCK2 | |
| SCHEMBL4854602 | 0.82 | GSK3B (0.63) | GSK3BNAMPTHDAC1KDM1ASORT1 | |
| Trifluoroacetic Acid SCHEMBL5655822 | 0.79 | GSK3B (0.59) | GSK3BNAMPTHDAC1KDM1ASORT1 | |
| SCHEMBL5235894 | 0.77 | GSK3B (0.57) | GSK3BP2RX7MAPK1ROCK2 | |
| SCHEMBL5229836 | 0.77 | GSK3B (0.52) | GSK3BHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5231874 | 0.77 | CASP1 (0.54) | GSK3BP2RX7MAPK1ROCK2 | |
| SCHEMBL5243212 | 0.74 | GSK3B (0.45) | GSK3BP2RX7MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581505-B1 | PYRIDAZINONE DERIVATIVES AS GSK-3BETA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-08-01 | — | — | EP | claimed |