Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243973 | 0.90 | TSHR (0.48) | MAPTGSK3BROCK2ROCK1KDM4E | |
| SCHEMBL5229171 | 0.89 | GSK3B (0.42) | MAPTGSK3BROCK2ALDH1A1MAPK1 | |
| SCHEMBL5229836 | 0.89 | GSK3B (0.52) | MAPTGSK3BTP53 | |
| SCHEMBL5229174 | 0.88 | GSK3B (0.43) | GSK3BROCK2MAPK1GRK2SMN1; SMN2 | |
| SCHEMBL5231874 | 0.87 | CASP1 (0.54) | GSK3BROCK2ROCK1KDM4EALDH1A1 | |
| SCHEMBL5243212 | 0.85 | GSK3B (0.45) | MAPTGSK3BTP53LMNAHPGD | |
| SCHEMBL5235894 | 0.85 | GSK3B (0.57) | GSK3BROCK2ROCK1MAPK1CASP1 | |
| SCHEMBL5227844 | 0.85 | GSK3B (0.57) | MAPTGSK3BTP53 | |
| SCHEMBL5228636 | 0.85 | GSK3B (0.48) | MAPTGSK3BTP53ALDH1A1LMNA | |
| SCHEMBL5232027 | 0.84 | EPHX1 (0.51) | MAPTGSK3BROCK2ROCK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611121-B1 | PYRIDAZINONE DERIVATIVES AS CDK2-INHIBITORS | AVENTIS PHARMA SA (FR) | 2007-08-08 | — | — | EP | claimed |
| EP-1581505-B1 | PYRIDAZINONE DERIVATIVES AS GSK-3BETA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-08-01 | — | — | EP | claimed |