Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13176733 | 0.72 | TDP1 (0.38) | TDP1LMNAL3MBTL1TSHRKDM4E | |
| SCHEMBL4935611 | 0.71 | — | — | |
| SCHEMBL5064969 | 0.69 | — | — | |
| SCHEMBL3927423 | 0.69 | — | — | |
| SCHEMBL1869405 | 0.69 | — | — | |
| SCHEMBL1869406 | 0.69 | — | — | |
| SCHEMBL1926252 | 0.67 | — | — | |
| SCHEMBL1089459 | 0.67 | — | — | |
| E968 SCHEMBL18493349 | 0.67 | TDP1 (0.77) | TDP1LMNAL3MBTL1TSHRKDM4E | |
| SCHEMBL12139121 | 0.67 | TDP1 (0.53) | TDP1LMNAL3MBTL1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228070-B1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |