⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28101553 | 0.78 | ALDH1A1 (0.31) | — | |
| SCHEMBL11597597 | 0.78 | — | — | |
| SCHEMBL2799985 | 0.75 | — | — | |
| SCHEMBL1287796 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL9576461 | 0.75 | — | — | |
| SCHEMBL8755927 | 0.73 | — | — | |
| Bicarbonate SCHEMBL686605 | 0.73 | ACHE (0.40) | — | |
| SCHEMBL15468786 | 0.73 | — | — | |
| Hydrogen Sulfide SCHEMBL27757959 | 0.71 | — | — | |
| SCHEMBL28405955 | 0.71 | ACHE (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101301294-A | Combinated inhibitors of FBP-ase and antidiabetic agents for diabetes treatment | METABEHJSIS TERAP JUTIKS INK (US) | 2008-11-12 | — | — | CN | disclosed |
| CN-100396283-C | Combination of FBP enzyme inhibitor and antidiabetic agent for treating diabetes | METABASIS THERAPEUTICS INC (US) | 2008-06-25 | — | — | CN | disclosed |
| EP-0868176-B1 | AMINOGUANIDINE FOR TREATING NIDDM | SMITHKLINE BEECHAM PLC (GB) | 2007-08-15 | — | — | EP | disclosed |
| CN-1599612-A | Combination of FBP enzyme inhibitor and antidiabetic agent for treating diabetes | METABASIS THERAPEUTICS INC (US) | 2005-03-23 | — | — | CN | disclosed |
| CN-1589304-A | Water-absorbing agent, method for producing same, and absorbent article using same | SAN DIA POLYMERS LTD (JP) | 2005-03-02 | — | — | CN | disclosed |
| CN-1097580-C | Aminoguanidine carboxylates for the treatment of non-insulin dependent diabetes mellitus | BIOVITRUM AB (SE) | 2003-01-01 | — | — | CN | disclosed |
| CN-1097580-C | Aminoguanidine carboxylates for the treatment of non-insulin dependent diabetes mellitus | BIOVITRUM AB (SE) | 2003-01-01 | — | — | CN | disclosed |
| EP-1001758-B1 | METHOD OF SCREENING OF POTENTIAL DRUGS AGAINST OBESITY, CAPABLE OF MODULATING THE REGULATION OF UCP-2 | BIOVITRUM AB (SE) | 2002-11-20 | — | — | EP | disclosed |
| US-20020082448-A1 | Aminoguanidine carboxylates for the treatment of non-insulin-dependent diabetes mellitus | THE UPJOHN COMPANY | 2002-06-27 | — | — | US | disclosed |
| US-6329545-B1 | SYSTEMIC ADMINISTRATION OF .ALPHA.-((AMINOIMINOMETHYL)HYDRAZONO)-BENZENEPROPANOIC ACID OR ITS HYDROCHLORIDE SALT FOR THERAPY OF DIABETES | LARSEN SCOTT D (US) | 2001-12-11 | — | — | US | disclosed |
| US-5955617-A | ALSO FOR TREATMENT OF IMPAIRED GLUCOSE TOLERANCE, OBESITY | PHARMACIA & UPJOHN COMPANY (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0912523-A1 | AMINOGUANIDINE CARBOXYLATE LACTAMS FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS | PHARMACIA & UPJOHN COMPANY (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1999000123-A1 | USE OF A DRUG CAPABLE OF MODULATING THE REGULATION OF UPC-2 AND METHOD FOR SCREENING FOR POTENTIAL DRUGS AGAINST OBESITY | PHARMACIA & UPJOHN AB (SE) | 1999-01-07 | — | — | WO | disclosed |
| WO-1997044324-A1 | AMINOGUANIDINE CARBOXYLATE LACTAMS FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS | PHARMACIA & UPJOHN COMPANY (US) | 1997-11-27 | — | — | WO | disclosed |
| CN-1164226-A | Aminoguanidine carboxylates for the treatment of non-insulin dependent diabetes mellitus | UPJOHN CO (US) | 1997-11-05 | — | — | CN | disclosed |
| CN-1164226-A | Aminoguanidine carboxylates for the treatment of non-insulin dependent diabetes mellitus | UPJOHN CO (US) | 1997-11-05 | — | — | CN | disclosed |
| US-4987129-A | BACTERICIDES | SANKEI PHARMACEUTICAL CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| US-4958019-A | Intermediates for synthesis of cephalosporin compounds | SANKEI PHARMACEUTICAL CO., LTD. (JP) | 1990-09-18 | — | — | US | disclosed |
| US-4956462-A | Bactericides, ANTIBIOTICS, CEPHALOSPORINS | SANKEI PHARMACEUTICAL CO., LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0302633-A2 | Beta-lactam compound, process for preparing the same, intermediate for synthesis of the same and medicinal composition for bacterially infectious disease therapy containing the same | SANKEI PHARMACEUTICAL COMPANY LIMITED (JP) | 1989-02-08 | — | — | EP | disclosed |