Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | CMA1 | P23946 | 4/20 | 0.60 |
| ▸ | PFKFB3 | Q16875 | 7/20 | 0.59 |
| ▸ | PFKFB4 | Q16877 | 6/20 | 0.59 |
| ▸ | HTR6 | P50406 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.52 |
| ▸ | HTR1B | P28222 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250288 | 0.86 | NPSR1 (0.74) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL12204617 | 0.83 | NPSR1 (0.90) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL5621183 | 0.77 | CMA1 (0.83) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL4463658 | 0.77 | CMA1 (0.83) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL8259082 | 0.76 | NPSR1 (0.76) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL8255568 | 0.76 | CMA1 (0.80) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL5621758 | 0.76 | PFKFB3 (0.80) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL6981823 | 0.76 | HTR6 (0.80) | NPSR1L3MBTL1CMA1PFKFB3HTR6 | |
| SCHEMBL2912913 | 0.75 | CMA1 (1.00) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL8255613 | 0.75 | CMA1 (1.00) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |
| EP-1519932-A1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | Cyclacel Limited (GB) | 2005-04-06 | — | — | EP | claimed |
| WO-2004005278-A1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LIMITED (GB) | 2004-01-15 | — | — | WO | claimed |