Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.76 |
| ▸ | CMA1 | P23946 | 3/20 | 0.66 |
| ▸ | PFKFB3 | Q16875 | 7/20 | 0.61 |
| ▸ | PFKFB4 | Q16877 | 6/20 | 0.60 |
| ▸ | HTR6 | P50406 | 8/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | HTR1D | P28221 | 5/20 | 0.55 |
| ▸ | HTR1B | P28222 | 5/20 | 0.55 |
| ▸ | HTR2C | P28335 | 4/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12204617 | 0.89 | NPSR1 (0.90) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL8255568 | 0.81 | CMA1 (0.80) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL5621758 | 0.81 | PFKFB3 (0.80) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL8250288 | 0.81 | NPSR1 (0.74) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL15480585 | 0.80 | CMA1 (0.77) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL4452960 | 0.79 | PFKFB3 (0.75) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL8255613 | 0.79 | CMA1 (1.00) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL8436628 | 0.78 | NPSR1 (0.70) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL2910759 | 0.77 | CMA1 (0.82) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 | |
| SCHEMBL3680145 | 0.77 | NPSR1 (0.69) | NPSR1L3MBTL1CMA1PFKFB3PFKFB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325920-B1 | N-SUBSTITUTED BENZOTHIOPHENESULFONAMIDE DERIVATIVES | TOA EIYO LTD (JP) | 2010-08-25 | — | — | EP | disclosed |
| US-7399781-B2 | N-substituted benzothiophenesulfonamide derivatives | TOA EIYO LTD. (JP) | 2008-07-15 | — | — | US | disclosed |
| US-20070032466-A1 | Drug containing chymase inhibitor as the active ingredient | TEIJIN PHARMA LIMITED (JP) | 2007-02-08 | — | — | US | disclosed |
| US-20070032466-A1 | Drug containing chymase inhibitor as the active ingredient | TEIJIN PHARMA LIMITED (JP) | 2007-02-08 | — | — | US | disclosed |
| US-20030229126-A1 | N-substituted benzothiophenesulfonamide derivatives | TOA EIYO LTD. | 2003-12-11 | — | — | US | disclosed |
| US-20030229126-A1 | N-substituted benzothiophenesulfonamide derivatives | TOA EIYO LTD. | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229126-A1 | N-substituted benzothiophenesulfonamide derivatives | ECE1, ECE2, CMA1 | NPSR1 88/4885L3MBTL1 3296/4885CMA1 3/4885 |
| US-20070032466-A1 | Drug containing chymase inhibitor as the active ingredient | REN, SERPINB1, CMA1 | NPSR1 1683/4885L3MBTL1 4241/4885CMA1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.