Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25332658 | 0.85 | DHODH (0.43) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL69159 | 0.78 | ALDH1A1 (0.58) | ALDH1A1KDM4EGLAGAAHPGD | |
| Hydrochloric Acid SCHEMBL5553175 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL29228925 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EGLAGAAHPGD | |
| Hydrochloric Acid SCHEMBL29161457 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL31622301 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL698811 | 0.75 | ALDH1A1 (0.51) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL2180242 | 0.72 | KDM4E (0.58) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL4908303 | 0.72 | BCAT2 (0.53) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL30002631 | 0.72 | ALDH1A1 (0.49) | ALDH1A1KDM4EGLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100358900-C | Novel compounds | ASTRAZENECA AB (SE) | 2008-01-02 | — | — | CN | disclosed |
| EP-1587809-B1 | THIENOPYRIDAZINONE DERIVATIVE AS MODULATORS OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| US-20060223809-A1 | Thieno [2,3,-d]pyridazin-4(5H)-ones; modulation of autoimmune diseases with T-cell antiproliferatives; antiinflammatory; organ transplant rejection; AIDS; chronic obstructive pulmonary disease (COPD); asthma | ASTRAZENECA AB, A SWEDEN CORPORATION | 2006-10-05 | — | — | US | disclosed |
| CN-1761670-A | Novel compounds | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | CN | disclosed |
| US-20060052380-A1 | Thieno [2,3,-d]pyridazin-4(5H)-ones; modulation of autoimmune diseases with T-cell antiproliferatives; antiinflammatory; organ transplant rejection; AIDS; chronic obstructive pulmonary disease (COPD); asthma | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223809-A1 | Thieno [2,3,-d]pyridazin-4(5H)-ones; modulation of autoimmune diseases with T-cell antiproliferatives; antiinflammatory; organ transplant rejection; AIDS; chronic obstructive pulmonary disease (COPD); asthma | CD4, IL5, CCR6 | ALDH1A1 1279/4885KDM4E 1171/4885GLA 4001/4885 |
| US-20060052380-A1 | Thieno [2,3,-d]pyridazin-4(5H)-ones; modulation of autoimmune diseases with T-cell antiproliferatives; antiinflammatory; organ transplant rejection; AIDS; chronic obstructive pulmonary disease (COPD); asthma | CD4, IL5, CCR6 | ALDH1A1 1279/4885KDM4E 1171/4885GLA 4001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.