Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222776 | 0.83 | PGR (0.47) | PGRPDE3BPDE3APDE4APDE4B | |
| SCHEMBL5230474 | 0.81 | PGR (0.50) | PGRPDE3BPDE3AEPHX2PDE4A | |
| SCHEMBL1222740 | 0.81 | PGR (0.55) | PGRPDE3BPDE3APDE4APDE4B | |
| SCHEMBL1223262 | 0.81 | PGR (0.55) | PGRPDE3BPDE3APDE4APDE4B | |
| SCHEMBL3990700 | 0.79 | PGR (0.58) | PGR | |
| SCHEMBL27448644 | 0.76 | PGR (0.47) | PGRPDE3BPDE3AEPHX2PDE4A | |
| SCHEMBL3987247 | 0.71 | PGR (0.43) | PGR | |
| SCHEMBL7128459 | 0.71 | PGR (0.44) | PGRPDE3BPDE3APDE4APDE4B | |
| SCHEMBL12886136 | 0.70 | PGR (0.65) | PGRPDE3BPDE3APDE4APDE4B | |
| SCHEMBL4809621 | 0.69 | PGR (1.00) | PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175398-B1 | INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS | WYETH CORP (US) | 2007-07-11 | — | — | EP | claimed |